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<h3>Job Description</h3>
Job DescriptionDEKA Research &amp; Development has an immediate opening for a Biocompatibility &amp; Toxicology Senior Scientist to join our team focused on medical device and combination product development. The individual in this role will work directly with Research &amp; Development, Regulatory &amp; Clinical Affairs and Quality Engineering to formulate and execute biocompatibility and toxicological evaluation strategies that support development objectives and world-wide regulatory approvals.&nbsp; How you will make a difference as a&nbsp;Biocompatibility &amp; Toxicology Senior Scientist:
<ul>
<li>Work in close association with customers and development teams to define and execute biocompatibility/toxicology evaluations, including establishing requirements for biological safety of medical devices and combination products</li>
<li>Lead the preparation and conduct of biocompatibility/toxicology test programs</li>
<li>Lead interactions with external consultants and contract laboratories including in-person meetings, teleconferences, and other communications as needed to support program objectives</li>
<li>Develop and deploy mechanisms to continually maintain state of the art knowledge and understanding related to biocompatibility and toxicological safety of medical devices, including relevant standards and test methods.&nbsp; Insure processes and procedures maximize resource efficiency and minimize time to market</li>
<li>Insure the organization stays up to date on global regulatory changes to medical device biocompatibility standards and requirements through monitoring regulatory authority and industry resources</li>
<li>Coach and mentor internal and external partners on effective strategies and tactics</li>
<li>Interface with customers on biocompatibility and toxicology issues</li>
</ul>
Skills you will need to be successful:
<ul>
<li>MS in a technically related field (toxicology, materials science, chemical engineering, biomedical engineering or related).</li>
<li>Minimum of 7 years direct work experience in a medical device and/or combination product development role with demonstrated success in planning and conducting biocompatibility and toxicological evaluations</li>
<li>Expertise in U.S. and international medical device biocompatibility requirements including ISO 10993 standards, Good Laboratory Practices, and guidance from regulatory authorities</li>
<li>Demonstrated practical knowledge of the laboratory methods and analytical techniques associated with medical device and/or combination product biocompatibility and chemical characterization evaluations</li>
<li>Demonstrated ability to establish consensus and work collaboratively across functions and development teams</li>
<li>Excellent written and verbal communication skills including the ability to effectively communicate at all levels of the organization and with external partners</li>
</ul>
About DEKA:
One hour from the beach, Boston, and the mountains, the historic Amoskeag Millyard once housed the largest textile mills in the world. It is now home to DEKA Research and Development, where we are taking the same innovation and cutting-edge technology into the modern age.
Behind DEKA’s brick walls sits a team of professionals who strive to make a difference every day through thoughtful engineering, design, and manufacturing. Here at DEKA, some of the most innovative and life-changing products of our time are created, and new ideas are always welcome and explored.
 &nbsp;
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5oUNcxSkY2

Biocompatibility & Toxicology Senior Scientist

<h3>Job Description</h3>
Job Description
Boston Metal is commercializing cutting­­-edge­ extractive metallurgy technology that will revolutionize primary metals production by improving metal quality while decreasing cost and lowering environmental impact. This fast-paced startup company is looking for a Senior Scientist to join the team. 
The Senior Scientist will collaborate with the R&amp;D team on the laboratory-scale research programs as well as with the process, operations, and engineering teams for the development activities of full-scale industrial experiments.
Responsibilities include but are not limited to:
<ul>
<li>Lead the development of electrometallurgical processes for new products using new feedstocks for our Critical Metals program.</li>
</ul>
<ul>
<li>Carry out thermodynamic and electrochemical calculations to support process development.</li>
</ul>
<ul>
<li>Track metrics such as conductivity, voltage, current efficiency, and specific energy consumption. </li>
</ul>
<ul>
<li>Collaborate with process development, engineering, operations, and supply chain to keep a focus on scalability while optimizing process parameters. </li>
</ul>
<ul>
<li>Conduct experiments and analyze data on existing high temperature electrochemical testing setup.</li>
</ul>
<ul>
<li>Regular presentation and communication of results within the technical team, to senior management, and company-wide.</li>
</ul>
Requirements
Strong theoretical background in electrochemistry with proven ability to perform data analysis and first-principles modeling, track record in novel electrochemical research, demonstrated ability to independently plan and implement research programs.
7+ years of experience with electrochemical research or metallurgy in a technical environment. MS/PhD from accredited university or college in one or more of the following areas: Materials Science, Chemical Engineering, Chemistry, process metallurgy or a closely related field. 
<ul>
<li>Demonstrated technical leadership experience</li>
<li>Experience with experimental electrochemical cell setup and characterization</li>
<li>Familiarity with chemical engineering principles (e.g., mass and energy balances, thermodynamics, transport phenomena)</li>
<li>Experience developing a MATLAB or Python based data analysis pipeline, and using graphical plotting software for data analysis and visualization</li>
<li>Experience in research and working with large datasets </li>
<li>Materials or metallurgical research</li>
<li>Experience with high-temperature setup/system</li>
<li>Experience with thermodynamic modeling and calculations (FactSage preferred)</li>
<li>Analysis Scripting in Matlab or Python</li>
<li>Experience using Labview</li>
<li>Materials characterization</li>
<li>Portuguese language experience preferred</li>
<li>Intermittent travel to our Brazil facility </li>
</ul>
Benefits
Additional Information:
We are people first with a comprehensive benefits package that can be customized to fit your needs. Our full benefits package offers health, dental, vision, life and disability insurance, paid vacation, sick &amp; holidays, health savings account with a company contribution, dependent care account plan, paid parental and bonding leave and a 401k with company matching provision.
You will be working in a small team environment where teamwork and good relationships with other team members is critical. We operate pilot plants and labs and many of our staff members are required to wear Personal Protection Equipment (PPE) and you should be prepared to do so as well when necessary.
Boston Metal is an equal opportunity employer who considers all qualified applicants equally for employment. We do not discriminate on the basis of race, color, religion, national origin, age, sex, gender identity, sexual orientation, pregnancy or pregnancy-related condition, disability, ancestry, genetic information, veteran or military status, or any other characteristics protected by applicable federal, state or local law.

Senior Scientist Critical Metals

<h3>Job Description</h3>
Job Description
Nanobiosym is an innovative nanotechnology company in Cambridge, MA, developing novel technologies to address a broad range of diseases. Nanobiosym was founded by an MIT/Harvard alum to work at the interface of physics, nanotechnology, and biomedicine. Nanobiosym was awarded the 2013 X-PRIZE- the first X-PRIZE ever awarded for healthcare.
DUTIES
<ul>
<li>Lead molecular diagnostic assay development in a hands-on manner through successful FDA submission</li>
<li>Manage and contribute to regulatory documents</li>
<li>Project management; personnel management skills preferred</li>
<li>Design assay performance specifications</li>
<li>Ensure assay development process meets milestones and timelines</li>
<li>Troubleshoot and solve technical issues</li>
<li>Maintain compliant laboratory documents and procedures</li>
<li>Pro-actively improve efficiency, quality and effectiveness of R &amp; D efforts</li>
</ul>
QUALIFICATIONS
<ul>
<li>PhD in Nucleic Acids Biochemistry, Molecular Biology, or related field</li>
<li>Minimum of 7 years of relevant industry experience and IVD assay development</li>
<li>In depth knowledge and hands on experience with qPCR, sequencing and standard molecular biology techniques</li>
<li>Demonstrated technical, managerial and leadership expertise in assay development</li>
<li>Strong understanding of FDA and global regulatory requirements</li>
<li>Prefer commercial assay experience</li>
<li>Demonstrated experience and understanding of quality systems (e.g., GLP, ISO, etc.)</li>
<li>Prefer experience working in BSL-2 laboratory facilities</li>
<li>Strong work ethic and ability to generate high quality work under tight deadlines</li>
<li>Flexibility in work schedule</li>
<li>Self-motivated, independent and a driving force of efficient execution</li>
<li>Strong organizational and project management skills</li>
<li>Excellent oral and written communication skills</li>
</ul>
 Job Posted by ApplicantPro

Senior Scientist: IVD Assay Developer

<h3>Job Description</h3>
Job Description
Xometry (NASDAQ: XMTR) powers the industries of today and tomorrow by connecting the people with big ideas to the manufacturers who can bring them to life. Xometry's digital marketplace gives manufacturers the critical resources they need to grow their business while also making it easy for buyers at Fortune 1000 companies to tap into global manufacturing capacity.
Xometry is seeking a Principal Data &amp; ML Scientist to join our Generative AI team. The ideal candidate will have a passion for advancing machine learning and generative AI capabilities, particularly for fine-tuning generative and language models, multimodal document understanding, and structured data extraction. This person will leverage their expertise in generative models and data science to develop and optimize innovative AI-driven solutions that enhance Xometry's service offerings.
Responsibilities:
<ul>
<li>Provide technical leadership to the Generative AI team, setting technical direction, defining best practices, and ensuring the team follows industry standards in AI and ML development.</li>
<li>Lead strategic planning and roadmap development for generative AI initiatives, identifying high-impact projects and aligning them with Xometry's business objectives.</li>
<li>Develop and deploy generative AI models and large language models (LLMs) for multimodal document processing, focusing on extracting structured data from technical drawings, purchasing orders, and other complex documents.</li>
<li>Lead the exploration and development of innovative text and image-based data processing solutions, including training and fine-tuning generative and language models.</li>
<li>Design and implement efficient workflows for data preparation, cleaning, and augmentation to support the training of generative AI models.</li>
<li>Utilize cloud platforms (e.g., Amazon Web Services) for large-scale data processing, model training, and deployment.</li>
<li>Collaborate with cross-functional teams, including engineering and business teams, to align generative AI solutions with business needs and drive impactful applications.</li>
<li>Mentor and guide team members on advanced machine learning techniques, model architecture design, and problem-solving strategies to elevate the team's technical capabilities.</li>
<li>Continuously experiment and iterate on model performance, tuning architectures and parameters to improve accuracy and efficiency in a fast-paced, agile environment.</li>
<li>Stay updated with the latest research in generative AI, deep learning, and multimodal data processing, incorporating best practices and advancements into model development.</li>
</ul>
Qualifications:
<ul>
<li>A bachelor's degree is required, but an advanced degree (M.S. or PhD) in computer science, machine learning, AI, or a related field is highly preferred.</li>
<li>7+ years of experience in data science and machine learning, focusing on generative models, LLMs, or computer vision.</li>
<li>Expertise in large-scale language and vision models (e.g., Transformers, GPT, VLMs).</li>
<li>Experience with multimodal data processing (e.g., combining text, image, and 3D data).</li>
<li>Proficient in Python, including key libraries such as PyTorch, TensorFlow, pandas, and numpy.</li>
<li>Strong background in probability, statistics, and optimization techniques relevant to generative modeling.</li>
<li>Familiarity with cloud computing resources and tools for model training and deployment (e.g., AWS SageMaker).</li>
<li>Familiar with software engineering principles, including version control, reproducibility, and continuous integration.</li>
<li>Experience in the manufacturing, supply chain, or similar industries is a plus.</li>
</ul>
#LI-Hybrid
Xometry is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
For US based roles: Xometry participates in E-Verify and after a job offer is accepted, will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.

Principal Machine Learning Data Scientist, Gen AI

<h3>Job Description</h3>
Job DescriptionCompany Description 
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at&nbsp;<a href="http://www.abbvie.com" target="_blank">www.abbvie.com</a>. Follow @abbvie on&nbsp;X,&nbsp;Facebook,&nbsp;Instagram,&nbsp;YouTube,&nbsp;LinkedIn&nbsp;and&nbsp;Tik Tok.
Job Description 
The Biologics Discovery Sciences Group at AbbVie is seeking an accomplished scientist to contribute significantly to the conception, execution, and communication of antibody discovery strategies in a highly collaborative environment. The successful candidate will develop and execute research strategies to advance the discovery and development of therapeutic antibodies for AbbVie’s core therapeutic areas. Key responsibilities include designing and executing in vitro display technologies for lead antibody identification and optimization. The candidate is also expected to generate internal and external collaborations to further program goals and drive antibody discovery programs within a multidisciplinary research group in a dynamic, fast-paced team setting.
Key Responsibilities:
<ul>
<li>Implement novel selection strategies and build industry-leading libraries for discovery and screening of therapeutic candidates.</li>
<li>Identify and solve technical problems independently; conceive and implement innovative research ideas.</li>
<li>Leverage expertise to develop and execute research for a detailed mechanistic understanding of therapeutic molecules' molecular pharmacology.</li>
<li>Provide project updates, analyses, and advice to cross-functional teams and senior management.</li>
<li>Present original work across departments and at scientific conferences; may author or co-author peer-reviewed scientific papers or patents.</li>
<li>Manage scientist(s), evaluate team performance, and ensure effective performance of the team.</li>
<li>Ensure consistency and quality of technical reports.</li>
<li>Engage with internal and external scientific leaders in collaborative research.</li>
<li>Serve as a biologics lead for cross-functional teams and contribute scientific insights into projects across various therapeutic areas; recognized as an expert in the discovery and engineering of therapeutic molecules.</li>
</ul>
Qualifications 
<ul>
<li>PhD, MS, or BS degree in Biochemistry, Biochemical Engineering, or related disciplines with typically 4-6&nbsp;(PhD), 10-12+ (MS), or 12-14+ (BS) years of experience.</li>
<li>Hands-on experience with in vitro antibody discovery display technologies (e.g., phage, yeast, mammalian).</li>
<li>Extensive experience and knowledge in antibody engineering and optimization, including humanization and Fc optimization.</li>
<li>Expertise in antibody and/or antibody fragment library design and construction.</li>
<li>Strong molecular biology skills.</li>
<li>Experience in displaying complex proteins (non-antibody-like) is preferred.</li>
<li>Familiarity with sequence analysis tools such as Geneious and PipeBio.</li>
<li>Experience with flow cytometry.</li>
<li>Ability to explore and develop new approaches to advance innovative in vitro discovery and screening technologies.</li>
<li>Excellent organizational skills and ability to manage multiple projects simultaneously.</li>
<li>Team player with the capability to operate in a fast-paced, multi-disciplinary environment and across functional and therapeutic areas.</li>
<li>Adaptability to rapid changes in project priorities and timelines.</li>
<li>Recognition in the scientific community, evidenced by a record of peer-reviewed publications and patents, is preferred.</li>
<li>Highly developed leadership and managerial experience is preferred.</li>
<li>Strong ability to engage with internal and external scientific leaders in collaborative research.</li>
</ul>
 Additional Information 
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or&nbsp;local law:&nbsp;​
<ul>
<li>
The compensation range described below is the range of possible base pay compensation that the Company&nbsp;believes in&nbsp;good faith it will pay for this role at the time&nbsp;of this posting based on the job grade for this position.&nbsp;Individual&nbsp;compensation paid within this range will depend on many factors including geographic location, and&nbsp;we&nbsp;may ultimately&nbsp;pay more or less than the posted range. This range may be modified in the&nbsp;future.​
</li>
<li>
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),&nbsp;medical/dental/vision&nbsp;insurance and 401(k) to eligible&nbsp;employees.​
</li>
<li>
This job is eligible to participate in our short-term incentive&nbsp;programs.&nbsp;​
</li>
<li>
This job is eligible to participate in our long-term incentive&nbsp;programs​
</li>
</ul>
​
Note: No amount of pay&nbsp;is considered to be&nbsp;wages or compensation until such amount is earned, vested, and&nbsp;determinable.&nbsp;The amount and availability of any bonus,&nbsp;commission, incentive, benefits, or any other form of&nbsp;compensation and benefits&nbsp;that are allocable to a particular employee remains in the Company's sole and&nbsp;absolute&nbsp;discretion unless and until paid and&nbsp;may be modified at the Company’s sole and absolute discretion, consistent with&nbsp;applicable law.&nbsp;
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.&nbsp;
US &amp; Puerto Rico only - to learn more, visit&nbsp;<a href="https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html" target="_blank">https://www.abbvie.com/join-us/equal-employment-opportunity-employer.ht…</a>
US &amp; Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
<a href="https://www.abbvie.com/join-us/reasonable-accommodations.html" target="_blank">https://www.abbvie.com/join-us/reasonable-accommodations.html</a>

Senior Scientist II, Biologics In Vitro Technologies

<h3>Job Description</h3>
Job DescriptionPrincipal Scientist, Translational Sciences Job summary: PharmaEssentia Innovation Research Center (PIRC) is seeking a highly motivated principal scientist to join our Translational Sciences team and contribute to the development of first-in-class and best-in-class biotherapeutics, including cytokines, antibodies, and antibody-drug-conjugates. &nbsp;The successful candidate will contribute to the design, execution, and interpretation of translational biomarker and mechanism of action (MOA) studies to support the development and regulatory approval of novel therapeutics as they transition from late discovery into first in human clinical trials and beyond.&nbsp; You will also drive translational and early clinical activities aimed at maximizing the potential of BESREMI, PharmaEssentia’s marketed drug for the treatment of myeloproliferative neoplasms, including indication expansion and novel combinations. &nbsp;To this end, you will work cross-functionally with clinical development, clinical operations, regulatory affairs as well as with academic investigators and clinical CROs to explore new applications for BESREMi.&nbsp; Additionally, you will provide scientific leadership, mentorship, and cross-functional collaboration within the Translational Sciences team and across other departments. The Company: It’s not often that you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You’ll find that rare opportunity at PharmaEssentia. Join us, and let’s transform lives, together. PharmaEssentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology, oncology and immunology, with one approved product and a diversifying pipeline. We believe in the potential to improve both the health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking. Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung. Our new research center, PharmaEssentia Innovation Research Center (PIRC), will build upon our invention and discovery-based innovation efforts originally established in Taiwan that led to a transformative advancement for treating polycythemia vera (one of the myeloid proliferative neoplasms). At PIRC, we aim to expand our current expertise in related therapeutic areas and identify novel therapeutic approaches in early to mid-stage discovery and development. Data scientists will leverage artificial intelligence and machine learning to inform new target and indication selection. The company is also recruiting for talented scientists who have deep knowledge in immunology, translational science, bioinformatics and biologics platforms to develop novel drugs leveraging disease-driving biology, novel technology in protein engineering, antibody discovery and new modalities. Summary of Key Responsibilities: &nbsp;
<ul>
<li>Further Exploration of BESREMi: Collaborate with clinical development to further explore the potential of BESREMi in MPN and other areas of Oncology. Conduct translational studies internally or externally via CROs, and drive investigator-initiated trials (IITs) or company sponsored clinical trials to maximize the clinical potential of BESREMi. </li>
<li>Study Design and Execution: Lead the design, planning, and execution of translational studies in indication-relevant animal models and primary human cellular and tissue systems to identify and validate biomarkers and explore drug candidate mechanism of action. &nbsp;Collaborate with cross-functional teams to ensure alignment with discovery and development goals as well as regulatory requirements.</li>
<li>Data Analysis and Interpretation: Oversee the analysis, interpretation, and reporting of in vitro and in vivo pharmacology/translational biomarker data, including pharmacokinetic and pharmacodynamic parameters, exposure-response relationships, and safety/tolerability profiles. Provide scientific insights to inform decision-making and optimize study outcomes.</li>
<li>Drug Development Strategy: Contribute to the development and implementation of clinical pharmacology strategies to support the progression of investigational drugs through all phases of clinical development. Generate scientific rationale for dose selection, formulation optimization, and therapeutic target validation.</li>
<li>Scientific Leadership: Serve as a subject matter expert in translational biomarkers, target biology and candidate therapeutic mechanism of action, providing guidance and mentorship to junior scientists, clinicians, and project teams. Contribute to the scientific literature through publications, presentations, and participation in professional conferences and working groups.</li>
<li>Cross-Functional Collaboration: Collaborate closely with colleagues in data sciences, biologics, immunology/pharmacology, clinical development, clinical operations and regulatory affairs to integrate translational biomarker and mechanism of action insights into overall drug development strategies. Foster a culture of scientific excellence, innovation, and collaboration. </li>
<li>Regulatory Interaction: Work with regulatory affairs and CROs to support the preparation and review of regulatory submissions, including investigational new drug (IND) applications, biologics license applications (BLA), and marketing authorization applications (MAA). Address inquiries and provide scientific justifications for study designs, endpoints, and data analyses.</li>
</ul>
 Qualifications: &nbsp;
<ul>
<li>M.D or Ph.D. in oncology, immunology, immuno-oncology, pharmacology, pharmaceutical sciences, or a related discipline.</li>
<li>8+ years’ experience in the pharmaceutical or biotechnology industries, including a proven track record of leadership and scientific achievement in translational sciences.</li>
<li>Expertise in in vivo model design and biomarker discovery, both internally and via CROs and academic collaborations. </li>
<li>Experience with primary human cellular/tissue-based assays to guide/inform indication selection, biomarker discovery and mechanism-of-action.</li>
<li>Experience with immuno-oncology and autoimmune disease/chronic inflammation targets and associated in vitro and in vivo models.</li>
<li>Experience in clinical trial design and/or clinical operations in either company-sponsored, or IIT clinical trials. </li>
<li>Experience working closely with academic collaborators and managing all aspects of sponsored research agreements or IITs.</li>
<li>Strong analytical skills, with proficiency in pharmacokinetic/pharmacodynamic software (e.g., NONMEM, Phoenix WinNonlin, R) is preferred.</li>
<li>Excellent communication and presentation skills, with the ability to effectively convey complex scientific concepts to diverse audiences.</li>
<li>Demonstrated leadership capabilities, including the ability to mentor and develop talent, foster teamwork, and drive results in a dynamic environment.</li>
</ul>
 Conclusion: As a Principal Scientist in Translational Sciences, you will play a pivotal role in advancing the understanding of drug pharmacology and contributing to the development of innovative therapeutics to address unmet medical needs. Your scientific expertise, leadership skills, and collaborative approach will be critical for driving drug development programs forward, maximizing the potential of BESREMi and ultimately improving patient outcomes at PIRC. EEO Statement: At PharmaEssentia Innovation Research Center (PIRC), we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PIRC believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool.&nbsp; PIRC does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PIRC employees. PIRC is not responsible for any fees related to unsolicited resumes from staffing agencies.
At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.
<a href="https://us.pharmaessentia.com/careers/" target="_blank">https://us.pharmaessentia.com/careers/</a>
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SymhRGPsqz

Principal Scientist, Translational Sciences

<h3>Job Description</h3>
Job Description
Position Summary
Solid Biosciences is seeking an experienced scientist to join our Downstream Process Development (DSPD) team. The DSPD team is responsible for the development, optimization, and technology transfer of the downstream purification processes of Solid’s gene therapy portfolio. The candidate will be a key collaborator in the company’s cross-functional deliverables, working with other groups such as Manufacturing Sciences &amp; Technology for scale-up and tech transfer, Analytical Development in pursuit of industry-leading AAV product quality, Research &amp; Development for designing next-generation purification schemes for novel delivery methods, and Upstream Process Development in the classic two-way collaboration between Process Development’s cell culture and purification sciences teams.
This role will focus on novel research and engineering efforts to invent and/or develop cutting-edge AAV purification technologies with a focus on scalable methods to enrich for high-potent AAV. As Solid continues to advance in the gene therapy space, this task will evolve to additional complex separations (e.g. removal of partially-filled capsids, separation of PTM variants such as deamidated species, and so on). The ability to continuously formulate new DSPD research topics and execute on them experimentally in continued pursuit of industry-leading AAV product quality and manufacturing cost of goods is key.
While this position will focus primarily on novel separations development, there will be ample need for the classical array of DSPD tasks. As such, laboratory mastery of DSPD fixtures such as programming ÄKTA FPLC methods, building and operating TFF skids, statistically-driven Design of Experiments, and sound scale-up principles is a must.
Key Duties &amp; Accountabilities
<ul>
<li>Creation and independent execution of downstream experimental designs</li>
<li>Literature and patent searching for staying abreast of industry trends and IP generation</li>
<li>Coordination with vendors and external partners to bring in and evaluate promising new technologies</li>
<li>Planning, setup, and execution with fellow downstream colleagues for high-workload purification deliverables (e.g. pilot runs)</li>
<li>Statistical interpretation of analytical test results and identification of most logical experimental paths forward</li>
<li>Collaboration with Research &amp; Development teams to create novel, rationally-designed purification schemes</li>
<li>Mentorship of junior team members in fundamental downstream techniques and concepts (associate scientists, co-op students)</li>
<li>Prepare technical reports, presentations, and documentation to support regulatory submissions (e.g., IND filings) and intellectual property development</li>
</ul>

Qualifications, Experience, and Skills Requirements
<ul>
<li>6+ years working in downstream process development or relevant PhD with 2+ years of industry experience</li>
<li>ÄKTA (UNICORN) method writing experience</li>
<li>Deep understanding of industry-standard chromatography (affinity, CEX, AEX, HIC)</li>
<li>Ability to formulate hypotheses, drive experimental work to key milestones and decision points, and present cost/benefit of continued resource allocation</li>
<li>TFF skid operation experience</li>
<li>Well-versed in historical and current analytical / characterization assays for biologics, AAV in particular</li>
<li>Design of Experiments software experience (e.g. JMP, MODDE, Minitab)</li>
<li>Data science and model building knowledge (e.g. random forest, nnet, ML/AI)</li>
</ul>
Preferred Qualifications
<ul>
<li>AAV / gene therapy experience a plus</li>
<li>Deep understanding of AAV biology and structure a plus</li>
<li>Deep understanding of unorthodox chromatographic modalities (mixed mode, metal affinity, etc.) a plus</li>
<li>Liquid handling/robocolumn automated chromatography experience a plus</li>
<li>Tech transfer document writing &amp; transfer to CDMO experience a plus</li>
</ul>
Travel Commitment
Some travel to external collaborators’ sites may be required; est. up to 10%.

Scientist II, Downstream

<h3>Job Description</h3>
Job Description
Biocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology. This role is ideal for candidates with broad expertise in pharmacological studies, disease model development, and cell-based assays, who are passionate about evaluating novel therapeutic agents for clients. 
The successful candidate will be a critical member of our fast-paced and expanding CRO team, actively engaging in both hands-on experimental work and strategic project management to support biotech and pharmaceutical partners
Key Responsibilities
In Vivo Pharmacology
<ul>
<li>Design and develop animal models, execute in vivo experiments to evaluate the biological efficacy of novel therapeutic agents.</li>
<li>Independently lead in vivo service projects and preclinical studies, acting as Project Manager or Study Director.</li>
<li>Perform animal handling, tumor inoculation, drug administration via multiple routes, blood and tissue collection, tumor measurements, and PK/PD studies.</li>
<li>Design and execute internal model-building projects and characterize various humanized mouse models.</li>
<li>Provide troubleshooting support and technical guidance to junior associates.</li>
<li>Collaborate closely with the BD/Sales team for client project planning and technical discussions.</li>
<li>Present project results to clients and internal stakeholders; prepare scientific reports and summaries.</li>
<li>Mentor and facilitate the growth of junior research associates.</li>
</ul>
In Vitro and Ex Vivo Pharmacology
<ul>
<li>Independently develop, validate, and perform a broad range of in vitro and ex vivo assays including:</li>
<ul>
<li>Immune cell profiling from blood and tissues.</li>
<li>Functional assays using primary cells (T cells, NK cells, macrophages).</li>
<li>Cytokine profiling, cytotoxicity, and apoptosis assays.</li>
</ul>
<li>Develop new assay technologies by researching scientific literature and adapting methodologies from collaborations and other internal teams.</li>
<li>Perform flow cytometry (FACS), ELISA, Western blot, qRT-PCR, and multiplex cytokine analyses.</li>
<li>Contribute to the design and support of in vivo pharmacology studies from an in vitro perspective.</li>
<li>Present research findings at internal meetings and contribute to external scientific discussions.</li>
</ul>
Requirements
<ul>
<li>PhD in pharmacology, immunology, cancer biology, or related biomedical field.</li>
<li>Extensive hands-on experience in animal models and preclinical in vivo pharmacology.</li>
<li>Proven skills in cell-based immunological assays including T cell activation, NK cell-mediated cytotoxicity, and macrophage functional assays.</li>
<li>Proficiency in PK/PD model establishment and analysis.</li>
<li>Expertise in flow cytometry, cytokine profiling (ELISA, qRT-PCR, multiplex assays), and immune cell isolation from tissues.</li>
<li>Experience with surgical procedures in rodents is highly desirable </li>
<li>Cross-functional knowledge across therapeutic areas is a plus.</li>
<li>Strong communication, organizational, and team collaboration skills with the ability to prioritize in a fast-paced environment.</li>
<li>Demonstrated ability to independently manage projects and work with cross-functional teams.</li>
</ul>
Benefits
<ul>
<li>Medical Insurance </li>
<li>Dental Insurance </li>
<li>Vision Insurance </li>
<li>Health Reimbursement Accounts </li>
<li>Life and AD&amp;D Insurance </li>
<li>Short &amp; Long Term Disability Insurance </li>
<li>401K with Company Match</li>
<li>Paid Time Off</li>
<li>Paid Sick Days &amp; Holidays </li>
</ul>
BIOCYTOGEN is an Equal Opportunity Employer. Employment opportunities at BIOCYTOGEN BOSTON CORP are based upon one’s qualifications and capabilities to perform the essential functions of a particular job. All employment opportunities are provided without regard to race, color religion, sex, national origin, ancestry, age, sexual orientation, gender identity and expression, veteran status, military status, disability, mental illness, genetic information, or any other characteristic protected by law. This Equal Employment Opportunity policy governs all aspects of employment, including, but not limited to, recruitment, hiring, selection, job assignment, promotions, transfers, compensation, discipline, termination, layoff, access to benefits and training, and all other conditions and privileges of employment.

Scientist/Senior Scientist for Pharmacology

<h3>Job Description</h3>
Job Description
Location: Devens MA
Reports to: Director, Separations Sciences
FLSA Status: Exempt
Summary:
The Principal Application Scientist is responsible for conducting chromatography services, developing chromatographic methodology and providing technical insights to YMC America customers. This is a hands-on lab position that will utilize YMC chromatography products to conduct lab services mainly at internal YMC facilities and occasionally externally at customer sites. The developed insights will be used for promoting YMC products and for technical support / troubleshooting of clients who use YMC products.
The Principal Application Scientist will also be responsible for technical support of YMC chromatography media, technology and lab systems. They will be a “face of YMC technology” at customer sites and conferences. This will include support of instrument rentals, feasibility studies, methods development and other activities that enable customers to solve purification dilemmas by leveraging YMC technologies.
Responsibilities:
<ul>
<li>Conduct certain YMC America’s lab studies (Insight Services) under the direction of the Director, Separations Sciences. Lab facilities include those in Devens, MA and certain university collaborations. This role includes some instrument maintenance and support for the in-house lab/pilot facility.</li>
<li>Maintain a high-level working knowledge of YMC chromatography products (resins, columns, services and systems) and impart that understanding in the support of sales as a non-sales technical expert.</li>
<li>Assist in internal and external bench chromatography (CUBE) and pilot (TWIN) studies in the America’s. This includes the occasional on-site and remote set-up and training of lab instruments (Contichrom CUBE).</li>
<li>Influence potential customers to recognize the value and benefits of YMC resin and system technologies in a non-sales role.</li>
<li>Attend conferences and technical meetings as a representative of YMC America. </li>
<li>Deliver occasional presentations, papers and / or posters at industry events. Generate reports on competitive techniques and technologies.</li>
<li>Co-author white papers / applications notes that can be used to promote understanding of YMC products.</li>
<li>Assist in the review of results from external users of YMC products and provide feedback on how to better use the product in question.</li>
<li>Troubleshoot existing customer separation problems when their technical experiences / insights are applicable.</li>
<li>Play an active role in the development of new applications for existing analytical and prep products. </li>
</ul>
Required Experience &amp; Knowledge:
<ul>
<li>Bachelor’s degree in chemistry, chemical engineering, or a related field.</li>
<li>A minimum of three years’ experience as a lab scientist with an emphasis on Chromatography. </li>
<li>Must have a solid knowledge of chromatographic theory, techniques and associated instruments.</li>
<li>Hands-on experience with prep chromatography techniques and instrumentation. Particularly, as applied to peptide and/or oligonucleotide pharmaceutical compounds.</li>
<li>Ability to prioritize obligations, make self-directed decisions, multi-task, and function effectively with multiple deadlines. </li>
<li>Must be willing to travel up to 20% of the time.</li>
<li>Must possess strong documentation and technical writing skills and be able to apply relevant scientific principles and practices.</li>
<li>Must communicate clearly and concisely across levels, both orally and in writing, with a strong command of the English language.</li>
<li>Must be able to work under minimal supervision and able to work independently and in a team environment.</li>
</ul>
Preferred Skills and Experience:
<ul>
<li>A post-undergraduate degree in Chemistry, Chemical Engineering, or a related degree.</li>
<li>Experience of 3+ years performing lab services preferably related to the pharmaceutical industry, including some form of lab management responsibilities.</li>
<li>Working knowledge of automation systems for lab and production equipment in the life sciences related field.</li>
<li>Demonstrated experience in writing technical papers. Past publication experience is a plus.</li>
<li>Working knowledge of both large molecule biopharmaceutical processes and small molecule processes.</li>
<li>Language/communication skills with Spanish, German or Japanese is preferred.</li>
</ul>

PRINCIPAL APPLICATION SCIENTIST

<h3>Job Description</h3>
Job DescriptionCompany Description 
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at&nbsp;<a href="http://www.abbvie.com" target="_blank">www.abbvie.com</a>. Follow @abbvie on&nbsp;X,&nbsp;Facebook,&nbsp;Instagram,&nbsp;YouTube,&nbsp;LinkedIn&nbsp;and&nbsp;Tik Tok.
Job Description 
The Analytical Research &amp; Development team is seeking a talented, highly motivated candidate with experience in the characterization of peptide and oligonucleotide biomolecules.&nbsp; The successful candidate will be responsible for leading the design, development, and implementation of analytical methods for the characterization of peptides/oligonucleotides using advanced analytical techniques, with an emphasis on high order characterization.&nbsp; We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&amp;D team and can offer exciting and rewarding career opportunities for these candidates. The ideal candidate will have significant CMC expertise in analytical development for biomolecule therapeutics. The candidate will be responsible for assisting with the development and execution of analytical methods to support CMC and will participate in phase-appropriate characterization of material and products at all stages of the development process, as well as monitoring completion of tasks and projects.
Responsibilities:
<ul>
<li>Lead development and implementation of advanced analytical characterization methods to support complex peptide and oligonucleotide development programs.&nbsp;</li>
<li>Utilize cutting-edge structure elucidation techniques (e.g., high-resolution, tandem mass spectrometry) to characterize a wide range of modalities across AbbVie’s pipeline, including oligonucleotide, peptide, and small molecule APIs, starting materials, intermediates, and impurities.</li>
<li>Lead cross-functional teams and collaborate with multi-disciplinary experts to develop strategies to enable the structure elucidation aspects of a project to advance programs through the development pipeline.</li>
<li>Advance scientific expertise beyond ARD organization. Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor and train colleagues and assesses current and emerging business challenges enabling functional goal achievement.</li>
<li>Ensure quality and effectiveness of key results of major project plans through sound design, early risk assessments, and implementation of fallback strategies.</li>
<li>Source and identify emerging scientific trends in the field of molecular characterization of therapeutics from internal and external sources and assess relevance. Integrate trends into functional short-term objectives. Advance cross discipline technology and direction within area of discipline.</li>
<li>Apply imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas across disciplines.</li>
<li>Make significant contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.</li>
<li>Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances and respond with appropriate new strategies.</li>
</ul>
Qualifications 
<ul>
<li>PhD (with 10+ years’ experience) in scientific discipline (e.g., Analytical Chemistry, Biochemistry, Chemical Biology or related field) with previous laboratory experience.</li>
<li>Deep understanding of peptide and/or oligonucleotide characterization, including higher order structure, chiral identification, and comparability assessments by mass spectrometry and other biophysical techniques (e.g. optical spectroscopy, structure, and binding).&nbsp; Experience in biomolecule analysis and interpretation by NMR spectroscopy a plus.</li>
<li>Practical experience and strong knowledge of LC separations (e.g., IP-RP LC, SEC), capillary electrophoresis, and other separation techniques as applied to peptide/oligonucleotide analysis.</li>
<li>Must possess demonstrated experience in peptide/oligonucleotide chemistry and biochemistry, particularly in the high order characterization activities &nbsp;related to drug development process and formulation characterization.</li>
<li>Experiences with the project leadership in the development of peptides and traditional small molecule modalities.</li>
<li>Proven ability to innovate with a history of new or improved product release.</li>
<li>High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.</li>
</ul>
 Additional Information 
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or&nbsp;local law:&nbsp;​
<ul>
<li>
The compensation range described below is the range of possible base pay compensation that the Company&nbsp;believes in&nbsp;good faith it will pay for this role at the time&nbsp;of this posting based on the job grade for this position.&nbsp;Individual&nbsp;compensation paid within this range will depend on many factors including geographic location, and&nbsp;we&nbsp;may ultimately&nbsp;pay more or less than the posted range. This range may be modified in the&nbsp;future.​
</li>
<li>
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),&nbsp;medical/dental/vision&nbsp;insurance and 401(k) to eligible&nbsp;employees.​
</li>
<li>
This job is eligible to participate in our short-term incentive&nbsp;programs.&nbsp;​
</li>
<li>
This job is eligible to participate in our long-term incentive&nbsp;programs​
</li>
</ul>
​
Note: No amount of pay&nbsp;is considered to be&nbsp;wages or compensation until such amount is earned, vested, and&nbsp;determinable.&nbsp;The amount and availability of any bonus,&nbsp;commission, incentive, benefits, or any other form of&nbsp;compensation and benefits&nbsp;that are allocable to a particular employee remains in the Company's sole and&nbsp;absolute&nbsp;discretion unless and until paid and&nbsp;may be modified at the Company’s sole and absolute discretion, consistent with&nbsp;applicable law.&nbsp;
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.&nbsp;
US &amp; Puerto Rico only - to learn more, visit&nbsp;<a href="https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html" target="_blank">https://www.abbvie.com/join-us/equal-employment-opportunity-employer.ht…</a>
US &amp; Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
<a href="https://www.abbvie.com/join-us/reasonable-accommodations.html" target="_blank">https://www.abbvie.com/join-us/reasonable-accommodations.html</a>

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